Wake-promoting agents: search for next generation modafinil: part II

Derek Dunn; Greg Hostetler; Mohamed Iqbal; Patricia Messina-McLaughlin; Alyssa Reiboldt; Yin Guo Lin; John Gruner; Edward R Bacon; Mark A Ator; Sankar Chatterjee

doi:10.1016/j.bmcl.2012.01.064

Wake-promoting agents: search for next generation modafinil: part II

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2315-7. doi: 10.1016/j.bmcl.2012.01.064. Epub 2012 Jan 28.

Authors

Derek Dunn¹, Greg Hostetler, Mohamed Iqbal, Patricia Messina-McLaughlin, Alyssa Reiboldt, Yin Guo Lin, John Gruner, Edward R Bacon, Mark A Ator, Sankar Chatterjee

Affiliation

¹ Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.

PMID: 22341942
DOI: 10.1016/j.bmcl.2012.01.064

Abstract

In search of a next generation molecule to modafinil, a novel wake promoting agent, we previously disclosed bi-phenyl derived racemate compound (±)-2 as a new generation of wake-promoting agent. Here we describe the profiles of the individual enantiomers (-)-2 and (+)-2, respectively.

MeSH terms

Animals
Area Under Curve
Biphenyl Compounds / chemical synthesis*
Biphenyl Compounds / pharmacokinetics
Biphenyl Compounds / pharmacology
Central Nervous System Stimulants / chemical synthesis*
Central Nervous System Stimulants / pharmacokinetics
Central Nervous System Stimulants / pharmacology
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System / metabolism
Electroencephalography
Injections, Intraperitoneal
Motor Activity / drug effects
Rats
Rats, Sprague-Dawley
Retinoic Acid 4-Hydroxylase
Sleep / drug effects
Stereoisomerism
Structure-Activity Relationship
Wakefulness / drug effects*
Wakefulness / physiology

Substances

Biphenyl Compounds
Central Nervous System Stimulants
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Retinoic Acid 4-Hydroxylase